The Laboratory of Dennis J. Selkoe, M.D.

Harvard Medical School
Center for Neurologic Diseases
Brigham & Women’s Hospital, Boston, MA

Selkoe Publications 1980-1989

Rothenberg S, Schottenfeld S, Gross K, Selkoe DJ.  Specific oculomotor deficit after acute methadone, I: Saccadic eye movements. Psychopharm. 1980; 67:221-227.

Rothenberg S, Schottenfeld S, Selkoe DJ, Gross K.  Specific oculomotor deficit after acute methadone, II:  Smooth pursuit eye movements. Psychopharm. 1980; 67:229-234.

Selkoe DJ.  Disease-related protein changes in purified neurons from Alzheimer’s and Huntington’s diseases.  TransAmerNeurolAssoc. 1980; 104:1-5.

Selkoe DJ.  Altered protein composition of isolated human cortical neurons in Alzheimer disease.  AnnNeurol. 1980; 8:468-478.

Selkoe DJ, Salazar FJ, Brown BA, Marotta CA.  Characterization of altered neuronal proteins in Alzheimer disease.  TransAmerNeurolAssoc. 1981; 105:1-4.

Breuer AC, Cuervo H, Selkoe DJ.  Contralateral hyperpathia and segmental sensory level due to parietal lobe arteriovenous malformation.  ArchNeurol. 1981; 38:722-724.

Borges LF, Hallett M, Selkoe DJ, Welch K.  The anterior tarsal tunnel syndrome. JNeurosurg.  1981; 54:89-92.

Selkoe DJ, Brown BA, Salazar FJ, Marotta CA.  Myelin basic protein in Alzheimer disease neuronal fractions and mammalian neurofilament preparations.  AnnNeurol. 1981; 10:429-436.

Rothenberg S, Selkoe DJ.  Specific oculomotor deficit after diazepam, I:  Saccadic eye movements.  Psychopharm. 1981; 74:232-236.

Rothenberg S, Selkoe DJ.  Specific oculomotor deficit after diazepam, II:  Smooth pursuit eye movements.  Psychopharm. 1981; 74:237-241.

Selkoe DJ, Ihara Y, Salazar FJ.  Alzheimer’s disease:  Insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea.  Science 1982; 215:1243-1245.

Selkoe DJ, Salazar FJ, Abraham C, Kosik KS:  Huntington’s disease:  Changes in striatal proteins reflect astrocytic gliosis.  BrainRes. 1982; 245:117-125.

Dahl D, Selkoe DJ, Pero RT, Bignami A.  Immunostaining of neurofibrillary tangles in Alzheimer’s senile dementia with a neurofilament antiserum.  JNeurosci. 1982; 2:113-119.

Kosik KS, Gilbert JM, Selkoe DJ, Strocchi P.  Characterization of post-mortem human brain proteins by two-dimensional gel electrophoresis.  JNeurochem. 1982; 39:1529-1538.

Selkoe DJ, Abraham C, Ihara Y.  Brain transglutaminase:  In vitro  crosslinking of human neurofilament proteins into insoluble polymers.  ProcNatlAcadSciUSA 1982;79:6070-6074.

Kosik KS, Bradley WG, Good PF, Rasool CG, Selkoe DJ.  Cholinergic function in focal lumbar aluminum myelopathy.  JNeuropatholExpNeurol. 1983; 42:365-375.

Ihara Y, Abraham C, Selkoe DJ.  Antibodies to paired helical filaments in Alzheimer’s disease do not recognize normal brain proteins.  Nature  1983; 304:727-730.

Rasool CG, Abraham C, Anderton BH, Haugh M, Kahn J, Selkoe DJ.  Alzheimer’s disease:  Immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies.   BrainRes. 1984; 310:249-260.

Rasool CG, Selkoe DJ.  Alzheimer’s disease:  Exposure of neurofilament immunoreactivity in SDS-insoluble paired helical filaments. BrainRes. 1984; 322:194-198.

Kosik KS, Selkoe DJ, Sapirstein V.  Possible modifications of vimentin following acquisition of Triton insolubility.  BiochemInternat. 1984; 9:483-490.

Kosik KS, Duffy LK, Dowling MM, Abraham C, McCluskey A, Selkoe DJ.   Microtubule associated protein 2:  Monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.  ProcNatlAcadSciUSA 1984; 81:794l-7945.

Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Duffy LK.  Production and             characterization of monoclonal antibodies to Alzheimer paired helical filaments.  AnnNYAcadSci. 1985; 455:744-778.

Rasool CG, Selkoe DJ.  Sharing of specific antigens by degenerating neurons in Pick’s disease and Alzheimer’s disease.  NewEnglJMed. 1985; 312:700-705. 

Kosik KS, McCluskey AH, Walsh FX, Selkoe DJ.  Axonal transport of cytoskeletal proteins in aluminum toxicity.  NeurochemPathol. 1985; 3:99-108.

Kirschner DA, Abraham C, Selkoe DJ.  X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer’s disease indicates cross-beta conformation. Proc Natl Acad Sci USA 1986; 83:503-507.

Selkoe DJ, Abraham CR, Podlisny M, Duffy LK.  Isolation of low molecular weight proteins from amyloid plaque fibers in Alzheimer’s disease.  JNeurochem. 1986; 46:1820-1834.

Kosik KS, Joachim CL, Selkoe DJ.  Microtubule-associated protein, tau, is a major antigenic component of paired helical filaments in Alzheimer’s disease.  ProcNatlAcadSciUSA 1986; 83:4044-4048.

Rasool CG, Svendsen C, Selkoe DJ.  Neurofibrillary degeneration of cholinergic and non-cholinergic neurons of the basal forebrain in Alzheimer’s disease.  AnnNeurol. 1986; 20:482-488.

Kosik KS, Bakalis S, Selkoe DJ, Pierce MW, Duffy LK. High molecular weight microtubule- associated proteins:  Purification by electro-elution and amino acid compositions. JNeurosciRes. 1986; 15:543-551.

Perry G, Selkoe DJ, Block BR, Stewart D, Autilio-Gambetti L, Gambetti P.   Electron microscopic localization of Alzheimer neurofibrillary tangle components recognized by an antiserum to paired helical filaments.  JNeuropatholExpNeurol. 1986; 45:161-168.

Neve R, Selkoe DJ, Kurnit DM, Kosik KS.  A cDNA for a human microtubule-associated protein 2 epitope in the Alzheimer neurofibrillary tangle.   JMolBrainRes. 1986; 1:193-196.

Selkoe DJ, Abraham CR.  Isolation of paired helical filaments and amyloid fibers from human brain.  MethEnzymol. 1986; 134:388-404.

Selkoe DJ, Bell DS, Podlisny MB, Price DL, Cork LC.  Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer’s disease.  Science 1987; 235:873-877.

Nukina N, Kosik K, Selkoe DJ.  Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to cross-reaction with tau protein.  ProcNatlAcadSciUSA 1987; 84:3415-3419.    

Joachim CL, Morris J, Kosik KS, Selkoe DJ. Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders.  AnnNeurol. 1987; 22:514-520.

Joachim CL, Morris J, Selkoe DJ, Kosik KS.  Tau epitopes are incorporated into a range of lesions in Alzheimer’s disease. JNeuropatholExpNeurol. 1987; 46:611-622.

Eidelberg D, Sotrel A, Joachim C, Selkoe D, Forman A, Pendlebury WW, Perl DP. Adult onset Hallervorden-Spatz disease with neurofibrillary pathology.  Brain 1987; 110:993-1013.

Kirschner DA, Inouye H, Duffy LK, Sinclair A, Lind M, Selkoe DJ.  Synthetic peptide homologous to ß protein from Alzheimer disease forms amyloid-like fibrils in vitro.  ProcNatlAcadSciUSA 1987; 84:6953-6957.

Podlisny MB, Lee G, Selkoe DJ.  Gene dosage of the amyloid ß precursor protein in Alzheimer’s disease.  Science 1987; 238:669-671.

Munoz DG, Greene C, Perl DP, Selkoe DJ.  Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients.  JNeuropatholExpNeurol. 1988; 47:9-18.

Abraham CA, Selkoe DJ, Potter H.  Immunochemical identification of the serine protease inhibitor, a1-antichymotrypsin, in the brain amyloid deposits of Alzheimer’s disease. Cell 1988; 52:487-501.

Nukina N, Kosik KS, Selkoe DJ.  The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer’s disease brain.  NeurosciLett. 1988; 87:240-246.

Joachim CL, Morris JH, Selkoe DJ.  Clinically diagnosed Alzheimer’s disease: autopsy results in 150 cases.  AnnNeurol. 1988; 24:50-56.

Cork LC, Powers RE, Selkoe DJ, Davies P, Geyer JJ, Price DP.  Neurofibrillary tangles and senile plaques in aged bears.  JNeuropatholExpNeurol. 1988; 47:629-641.

Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz LC, Oltersdorf T.  ß-amyloid precursor protein of Alzheimer’s disease occurs as 110- to 135 kilodalton membrane-associated proteins in neural and nonneural tissues.  ProcNatlAcadSciUSA 1988; 85:7341-7345.

Joachim CL, Duffy LK, Morris JH, Selkoe DJ.  Protein chemical and immunocytochemical studies of meningovascular ß-amyloid protein in Alzheimer’s disease and normal aging.  BrainRes. 1988; 474:100-111.

Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG.  Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer’s disease and recognize senile plaques. BiochemBiophysResCommun. 1988; 156:432-437.

Whitson JS, Selkoe DJ, Cotman CW.  Amyloid ß protein enhances the survival of hippocampal neurons in vitro.  Science 1989; 243:1488-1490.

Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, and Younkin SG.  The ß amyloid protein precursor of Alzheimer’s disease has soluble derivatives found in human brain and cerebrospinal fluid.  ProcNatlAcadSci USA 1989; 86:6338-6342.

Joachim CL, Morris JH, Selkoe DJ.  Diffuse amyloid plaques occur commonly in the cerebellum in Alzheimer’s disease.  AmJPath. 1989; 135:309-319.

Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC.  a1-antichymotrypsin is present together with the ß-protein in monkey brain amyloid deposits.  Neuroscience 1989;32:715-720.

Forno LS, Eng F, Selkoe DJ.  Pick bodies in the locus ceruleus.  ActaNeuropathol. 1989; 79:10-17.

Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe DJ.  Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.  JNeuroimmunol. 1989; 24:173-182.

Joachim CL, Mori H, Selkoe DJ.  Amyloid ß-protein deposition in tissues other than brain in Alzheimer’s disease.  Nature 1989; 341:226-230.

Palmert MR, Siedlak SL, Podlisny MB, Greenberg B, Shelton ER, Chan HW, Usiak M, Selkoe DJ, Perry G, Younkin SG.  Soluble derivatives of the ß amyloid protein precursor of Alzheimer’s disease are labeled by antisera to the ß amyloid protein.  BiochemBiophysResCommun. 1989; 165:182-188.