The Laboratory of Dennis J. Selkoe, M.D.

Harvard Medical School
Center for Neurologic Diseases
Brigham & Women’s Hospital, Boston, MA

Selkoe Publications 1990-1999

Podlisny MB, Mammen AL, Schlossmacher MG, Palmert MR, Younkin SG, Selkoe DJ.  Detection of soluble forms of the ß-amyloid precursor protein in human plasma.  BiochemBiophysResCommun. 1990; 167:1094-1101.

Bodmer S, Podlisny MB, Selkoe DJ, Heid I, Fontana A.  Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer’s disease.  BiochemBiophysResCommun. 1990; 171:890-897.

Joachim C, Games D, Morris J, Ward P, Frenkel D, Selkoe D.  Antibodies to non-ß regions of the ß-amyloid precursor protein detect a subset of senile plaques.  AmJPathol. 1991; 138:373-384.

Podlisny MB, Tolan DR, Selkoe DJ. Homology of the amyloid beta-protein precursor in monkey and human supports a primate model for beta-amyloidosis in Alzheimer’s disease.  AmJPathol. 1991; 138:1423-1435.

Haass C, Hung AY, Selkoe DJ.  Processing of ß-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion.  JNeurosci. 1991; 11:3783-3793.

Tamaoka A, Kalaria RN, Lieberburg I, Selkoe DJ.  Identification of a stable fragment of the Alzheimer amyloid precursor containing the ß-protein in brain microvessels.  ProcNatlAcadSciUSA 1992; 89:1345-1349.

Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG.  Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.  Science 1992; 255:728-730.

Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ.  Detection of distinct isoform patterns of the ß-amyloid precursor protein in human platelets and lymphocytes.  NeurobiolAging 1992; 13:421-434.

Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ.  Targeting of cell surface ß-amyloid precursor protein to lysosomes:   Alternative processing into amyloid-bearing fragments.  Nature 1992; 357:500-503.

Yamaguchi H, Yamazaki T, Lemere CL, Frosch MP, Selkoe DJ.  Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer’s disease.  AmJPathol. 1992; 141:249-259.

Mori H, Takio K, Ogawara M, Selkoe DJ.  Mass spectrometry of purified amyloid ß protein in Alzheimer’s disease.  JBiol Chem. 1992; 267:17082-17086.

Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, Selkoe DJ.  Amyloid ß-peptide is produced by cultured cells during normal metabolism.  Nature 1992; 359:322-325.

Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C, McCormack R, Wolfert R, Selkoe D, Lieberburg I, Schenk D.  Isolation and quantification of soluble Alzheimer’s ß-peptide from biological fluids.  Nature 1992; 359: 325-327.

Podlisny MB, Stephenson DT, Frosch MP, Lieberburg I, Clemens JA, Selkoe DJ.  Synthetic amyloid ß-protein fails to produce specific neurotoxicity in monkey cerebral cortex.  NeurobiolAging 1992; 13:561-567.

Hung AY, Koo EH, Haass C, Selkoe DJ.  Increased expression of ß-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. ProcNatlAcadSciUSA 1992; 89:9439-9443.

Stephenson DT, Podlisny MB, Games D, Lieberburg I, Selkoe DJ, Clemens JA.  Effects of implants of ß-amyloid protein in monkey cerebral cortex.  Neurodegeneration 1992;1:177-187.

Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, Podlisny MB, Kirschner DA.  Fibril formation by primate, rodent and Dutch-hemorrhagic analogues of Alzheimer amyloid ß-protein.  Biochemistry 1992; 31:10716-10723.

Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ.  Mutation of the ß-amyloid precursor protein in familial Alzheimer’s disease causes increased ß-protein production.  Nature 1992; 360:672-674.

Podlisny MB, Stephenson DT, Frosch MP, Tolan DR, Lieberburg I, Clemens JA, Selkoe DJ.  Microinjection of synthetic amyloid ß-protein in monkey cerebral cortex fails to produce acute neurotoxicity.  AmJPathol. 1993; 142:17-24.

Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ.  ß-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.  JBiolChem. 1993; 268:3021-3024.

Koo EH, Park L, Selkoe DJ.  Amyloid ß-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.  ProcNatlAcadSciUSA 1993; 90:4748-4752.

Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ.  Activation of protein kinase C inhibits cellular production of the amyloid ß-protein. JBiolChem. 1993; 268:22959-22962.

Citron M, Haass C, Selkoe DJ.  Production of amyloid-ß-peptide by cultured cells:  no evidence for internal initiation of translation at Met596.  NeurobiolAging 1993; 14:571-573.

Askanas V, Engel WK, Bilak M, Alvarez RB, Selkoe DJ.  Twisted tubulofilaments of inclusion-body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau.  AmJPathol., 1994; 144:177-187.

Hung AY, Selkoe DJ.  Selective ectodomain phosphorylation and regulated cleavage of ß-amyloid precursor protein.  EMBOJ. 1994; 13:534-542.

Haass C, Koo EH, Teplow DB, Selkoe DJ.  Polarized secretion of ß-amyloid precursor protein and amyloid ß-peptide in MDCK cells.  ProcNatlAcadSciUSA 1994; 91:1564-1568.

Querfurth HW, Selkoe DJ.  Calcium ionophore increases amyloid ß peptide production by cultured cells.  Biochemistry 1994; 33:4550-4561.

Haass C, Hung AY, Selkoe DJ, Teplow DB.  Mutations associated with a locus for familial Alzheimer’s disese result in alternative processing of amyloid ß-protein precursor.  JBiolChem. 1994; 269:17741-17748.

Bons N, Mestre N, Ritchie K, Petter A, Podlisny M, Selkoe D.  Identification of amyloid beta protein in the brain of the short-lived Lemurian primate Microcebus Murinus.  NeurobiolAging; 1994; 15:215-221.

Maness LM, Banks WA, Podlisny MG, Selkoe DJ, Kastin AJ.  Passage of human amyloid ß-protein 1-40 across the murine blood-brain barrier.  LifeSci. 1994; 55:1643-1650.

Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS.  Secreted ß-amyloid precursor protein stimutates mitogen-activated protein kinase and enhances tau phosphorylation. 

ProcNatlAcadSciUSA 1994; 91:7104-7108.

Citron M, Vigo-Pelfrey C, Teplow DB, Miller C, Schenk D, Johnston J, Winblad B, Venizelos N, Lannfelt L, Selkoe DJ.  Excessive production of amyloid ß-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer’s disease mutation.  ProcNatlAcadSciUSA 1994; 91:11993-11997.

Citron M, Teplow DB, Selkoe DJ.  Generation of amyloid ß-protein from its precursor is sequence specific.  Neuron 1995; 14: 661-670.

Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ.  The vacuolar H+ ATPase inhibitor Bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type ß-amyloid precursor protein.  JBiolChem. 1995; 270:6186-6192.

Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ.  Polarized sorting of ß-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.  JCellBiol. 1995; 128:537-547.

Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ.  Cell-surface ß-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. JNeurosci. 1995; 15: 2157-2167.

Querfurth HW, Wijsman EM, St. George-Hyslop PH, Selkoe DJ.  ßAPP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer’s disease-1 family.  MolBrainRes. 1995; 28: 319-337.

Lemere CA, Munger JS, Shi G-P, Natkin L, Haass C, Chapman HA, Selkoe DJ.  The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer’s disease and Down syndrome brain:  An immunocytochemical study.  AmJPathol.1995; 146: 848-860.

Yamazaki T, Selkoe DJ, Koo EH.  Trafficking of cell surface ß-amyloid precursor protein:  Retrograde and transcytotic transport in cultured neurons.  JCellBiol. 1995; 129: 431-442.

Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ.  Aggregation of secreted amyloid ß-protein into SDS-stable oligomers in cell culture.  JBiolChem. 1995; 270: 9564-9570.

Munger JS, Haass C, Lemere CA, Shi G-P, Wong F, Teplow DB, Selkoe DJ,Chapman HA.  Lysosomal processing of amyloid precursor protein to Aß peptides:  A distinct role for cathepsin S.  BiochemJ. 1995; 311: 299-305.

Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer’s disease by b-secretase cleavage within the secretory pathway.   NatureMed. 1995; 1: 1291-1296.

Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS.  Amino-terminal regional of the ß-amyloid precursor protein activates mitogen-activated protein kinase.  NeuroscienceLetters 1995; 198: 52-56.

Biere AL, Ostaszewski B, Zhao H, Gillespie S, Younkin SG, Selkoe DJ.  Co-expression of ß-amyloid precursor protein (ßAPP) and apolipoprotein E in cell culture:  analysis of ßAPP processing.  NeurobiologyofDisease 1995; 2: 177-187.

Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ.  Sequence of deposition of heterogeneous amyloid ß-peptides and APO E in Down syndrome:  Implications for initial events in amyloid plaque formation.  NeurobiologyofDisease 1996; 3: 16-32.

Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ.  Degradation of amyloid ß-protein by a serine protease/a2-macroglobulin complex.  JBiolChem. 1996; 271: 8443-8451.

Stephenson DT, Lemere CA, Selkoe DJ, Clemens JA.  Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer’s disease brain.  Neurobiology of Disease 1996;3: 51-63.

Koo EH, Squazzo SL, Selkoe DJ, Koo CH.  Trafficking of cell-surface amyloid ß-protein precursor  I.  Secretion, endocytosis, and recycling detected by labeled monoclonal antibody.  JCellSci. 1996; 109: 991-998.

Yamazaki T, Koo EH, Selkoe DJ.  Trafficking of cell-surface amyloid ß-protein precursor II.  Endocytosis, recycling, and lysosomal targeting detected by immunolocalization.  JCellSci. 1996; 109: 999-1008.

Tamaoka A, Endoh R, Shoji S, Takahashi H, Takahashi H, Hirokawa K, Teplow DB,Selkoe DJ, Mori H.  Antibodies to amyloid ß protein (Aß) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH).  NeurobiolAging 1996; 17, 405-414.

Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ.  Inhibition of amyloid ß-protein production in neural cells by the serine protease inhibitor, AEBSF.  Neuron 1996;17: 171-179.

Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, Selkoe DJ, Arango V JC.  The E280A presenilin 1 Alzheimer mutation produces increased Ab42 deposition and severe cerebellar pathology.  NatureMed. 1996; 2: 1146-1150.

Calingasan NY, Gandy SE, Baker H, Sheu K-FR, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GF.  Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.  AmJPathol. 1996; 149: 1063-1071.

Capell A, Teplow DB, Citron M, Selkoe DJ, Haass C.  (1996) Substituion of phenylalanine by proline at position 19 of amyloid b peptide results in an increased production of amyloid b peptides with alternative N-termini after protein kinase C stimulation.  Amyloid 1996; 3: 150-155.

Citron M, Diehl TS, Gordon G, Biere AL, Seubert P, Selkoe DJ.  Evidence that the 42- and 40-amino acid forms of amyloid b protein are generated from the b-amyloid precursor protein by different protease activities.  ProcNatlAcadSciUSA 1996; 93: 13170-13175.

Scheuner D, Eckman, C, Jensen, M, Song X, Citron M, Suzuki N, Bird TD, Hardy J,Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S.  Secreted amyloid b-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease.  NatureMed. 1996; 2: 864-870.

Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB,Fraser P, St. George-Hyslop P, Selkoe DJ, Haass C.  The Alzheimer’s disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.  MolMed. 1996; 2: 673-691.

Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ,Seeger M, Gandy SE, Price DL, Sisodia SS.  Protein topology of presenilin 1.  Neuron 1996; 17: 1023-1030.

Biere AL, Ostaszewski B, Stimson ER, Hyman BT, Maggio JE, Selkoe DJ.  Amyloid b-peptide is transported on lipoproteins and albumin in human plasma.  JBiolChem. 1996; 271: 32916-32922.

Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T.  The “non-amyloidogenic” p3 fragment (amyloid b17-42) is a major constituent of Down syndrome cerebellar preamyloid.  JBiolChem. 1996; 271: 33623-33631.

Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C.  Ectodomain phosphorylation of b-amyloid precursor protein at two distinct cellular locations.  JBiolChem. 1997; 272: 1896-1903.

Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George-Hyslop P, Selkoe DJ.  Mutant presenilins of Alzheimer’s disease increase production of 42-residue amyloid b-protein inboth transfected cells and transgenic mice.  NatureMedicine 1997; 3: 67-72.

Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ.  Degradation of amyloid ß-protein by a metalloprotease secreted by microglia and other neural and non-neural cells.  J Biol Chem. 1997; 272: 6641-6646.

Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EHM, Seubert P, St. George-Hyslop P, Teplow DB, Selkoe DJ.  Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.  Neurobiol Dis 1997; 3: 325-337.

Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ.  Enhanced production and oligomerization of the 42-residue amyloid ß-protein by Chinese hamster ovary cells stably expressing mutant presenilins.  J Biol Chem. 1997; 272: 7977-7982.

Yamazaki T, Koo EH, Selkoe DJ.  Cell surface amyloid ß-protein precursor colocalizes with ß1 integrins at substrate contact sites in neural cells.  J Neurosci. 1997; 17: 1004-1010.

Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S.  Skeletal and CNS defects in Presenilin-1 deficient mice.  Cell 1997; 89: 629-639.

Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, St George-Hyslop P, Multhaup G, Selkoe DJ, Haass C.  Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.  Proc Natl Acad Sci USA 1997; 94: 5349-5354.

Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells:  Implications for the pathogenesis of Alzheimer’s disease.  Proc Natl Acad Sci USA 1997; 94: 8208-8213.

Poduslo JF, Curran GL, Haggard JJ, Biere AL, Selkoe DJ.  Permeability and residual plasma volume of human, Dutch variant, and rat amyloid ß-protein 1-40 at the blood-brain barrier.  Neurobiol Dis 1997; 4: 27-34.

Watson DJ, Lander AD, Selkoe DJ.  Heparin-binding properties of the amyloidogenic peptides Aß and amylin:  Dependence on aggregation state and inhibition by Congo red.  J Biol Chem. 1997; 272: 31617-31624.

Querfurth HW, Jiang JW, Geiger JD, Selkoe DJ.  Caffeine stimulates amyloid beta-peptide release from b-amyloid precursor protein-transfected HEK293 cells. JNeurochem. 1997; 69: 1580-1591.

Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C.  The proteolytic fragments of the Alzheimer’s disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.  JBiolChem. 1998; 273: 3205-3211.

Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ.  A substrate-based difluoro ketone selectively inhibits Alzheimer’s g-secretase activity.  JMedChem. 1998; 41: 6-9.

Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ.  Oligomerization of endogenous and synthetic amyloid ß-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.  Biochemistry. 1998; 37: 3602-3611.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.  Presenilin 1 regulates the processing of ß-amyloid precursor protein C-terminal fragments and the generation of amyloid ß-protein in endoplasmic reticulum and Golgi.  Biochemistry 1998; 37: 16465-16471.

Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH.  Subcellular distribution and turnover of presenilins in transfected cells.  JBiolChem. 1998; 273: 12436-12442.

Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G,St. George Hyslop P, Younkin SG, Selkoe DJ.  Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid ß-protein.  NeurobiolDisease 1998; 5: 107-116.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR,  Safavi A,Hersh LB, Selkoe DJ.  Insulin-degrading enzyme regulates extracellular levels of amyloid ß-protein by degradation.  JBiolChem. 1998; 273: 32730-32738.

Xia M, Berezovska O, Kim T-W, Xia W-M, Liao A, Tanzi RE, Selkoe D, Hyman BT.  Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer’s disease.  JNeurological Sci. 1998; 158: 15-23.

Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C.  Expression of Alzheimer’s disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.  JBiolChem. 1998; 273: 32322-32331.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly, WT, Selkoe DJ.  Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and g-secretase activity.  Nature 1999; 398: 513-517.

Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO,Selkoe DJ.  Peptidomimetic probes and molecular modeling suggest Alzheimer’s g-secretase is an intramembrane-cleaving aspartyl protease.  Biochemistry 1999; 38: 4720-4727.

Wolfe MS, de Los Angeles J, Miller DD, Xia W, Selkoe DJ.  Are presenilins intramembrane-cleaving proteases?  Implications for the molecular mechanism of Alzheimer’s disease.  Biochemistry 1999; 38: 11223-11230.     

Lemere CA, Grenfell TJ, Selkoe DJ.  The AMY antigen occurs with Aß and follows its deposition in the amyloid plaques of Alzheimer’s disease and Down syndrome.  AmJPathol. 1999; 155: 29-37.

Watson DJ, Selkoe DJ, Teplow DB.  Effects of the APP Glu693®Gln “DUTCH” Mutation on Aß production and stability.  BiochemJ. 1999; 340: 703-709.

Poduslo JF, Curran GL, Sanyal B, Selkoe DJ.  Receptor-mediated transport of human amyloid ß-protein 1-40 and 1-42 at the blood-brain barrier.  Neurobiol. Disease 1999; 6: 190-199.

Querfurth HW, Jiang J, Xia W, Selkoe DJ.  Enhancer function and novel DNA binding protein activity in the near upstream ßAPP gene promoter.  Gene 1999; 232: 125-141.

Perez RG, Soriano S, Hayes JD, Chen X, Ostaszewski B, Stokin G, Selkoe DJ, Koo EH.  Mutagenesis identifies new signals for ß-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Aß42.  JBiolChem. 1999; 274: 18851-18856.

Ray WJ, Yao M, Mumm J, Schroeter EH, de Strooper B, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM.  Cell surface presenilin-1 participates in the g-secretase-like proteolysis of Notch.  J Biol Chem 1999; 274: 36801-36807.

Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ.  Protofibrillar intermediates of amyloid ß-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.  J Neurosci 1999; 19: 8876-8884.

Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB.  Amyloid ß-protein fibrillogenesis.  J. Biol. Chem. 1999; 274:25945-25952.