The Laboratory of Dennis J. Selkoe, M.D.

Harvard Medical School
Center for Neurologic Diseases
Brigham & Women’s Hospital, Boston, MA

Selkoe Publications Reviews

Selkoe DJ, Shelanski ML.  The neurochemistry of aging.  In: Scheinberg P, ed.CerebrovascularDiseases (Proc. X Princeton Conference).  New York:  Raven Press, 1976:357-371.

Selkoe DJ, Shelanski ML.  The fibrous proteins of brain.  In:  Nandy E, Sherwin I., eds., TheAgingBrainandSenileDementia.  New York:  Plenum Press, 1977:247-263.

Selkoe DJ.  Cerebral aging and dementia.  In:  Tyler HR, Dawson DM, eds., CurrentNeurology, Vol. 1.  Los Angeles:  Houghton Mifflin, 1978:360-387.

Liem RKH, Selkoe DJ, Yen S-H, Salomon G, Shelanski ML.  New insights on the chemistry of neurofilaments.  In:  Katzman R, ed., CongenitalandAcquiredCognitiveDisorders.  Assn Res Nerv Mental Dis. (ARNMD),  Research Publications. 1978; 57:143-152.

Selkoe DJ, Magner AM, Shelanski ML.  Pathology and biochemistry of the neurofilament in experimental and human neurofibrillary degeneration.  In: Cherkin A, Finch CE, Kharasch N et al., eds., PhysiologyandCellBiologyof Aging.  New York:  Raven Press, 1979:121-139.

Selkoe DJ.  Cerebral aging and dementia:  An update.  In:  Tyler HR, Dawson DM, eds., Neurology, Vol 2.  Los Angeles:  Houghton Mifflin, 1979:344-349.

Shelanski ML, Selkoe DJ.  Protein changes in the aging brain.  In:  Davison AN,

Thompson RHS, eds., The Molecular Basis of Neuropathology. London: Edward Arnold, 1981:591-600.

Selkoe DJ.  The human brain in normal aging and dementia.  In:  Steele K, ed., Geriatric Education.  Lexington, MA:  Collamore Press, 1981:149-160.

Selkoe DJ.  Molecular pathology of the aging human brain.  TrendsinNeurosciences. 1982; 5:332-336.

Kosik KS, Selkoe DJ.  Experimental models of neurofilamentous pathology. In:  Marotta CA, ed., Neurofilaments.  Minneapolis:  University of Minnesota Press, 1983.

Selkoe DJ, Kosik KS.  Neurochemical changes with aging.  In:  Albert MA, ed., TheClinicalNeurologyofAging.  New York:  Oxford Press, 1984: 53-57.

Selkoe DJ, Ihara Y, Abraham C, Rasool CG, McCluskey AH.  Biochemical and     immunocytochemical studies of Alzheimer paired helical filaments.  In:  Katzman R, ed., BanburyReport15:  BiologicalAspectsof Alzheimer’sDisease, New York:  Cold Spring Harbor Laboratory 1983:125-134.

Selkoe DJ.  Recent advances in Alzheimer’s disease.  In:  Petersdorf RG, Adams RD, Braunwald E, Isselbacher KJ, Martin JB, Wilson D., eds., Harrison’s Principles of Internal Medicine, Update V.  New York:  McGraw Hill, 1984:15-33.

Kosik KS, Ihara Y, Abraham C, Rasool CG, McCluskey A, Selkoe DJ.   Neurochemical studies of Alzheimer-type neurofibrillary degeneration and a related experimental model.  In:  Scarpelli D., ed., Comparative Pathobiology of Major Age-Related Diseases:  Current Status and Research Frontiers.  New York:  Alan R. Liss, 1984:373-384.

Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Kosik KS, Duffy LK.  Paired helical filaments in human neurons:  Relationship to neurofilaments. AnnNYAcadSci. (International Conference on Intermediate Filaments).  1985; 455:583-596.

Selkoe DJ, Abraham C, Rasool CG.  Biochemical and structural studies of paired helical filaments and senile plaque amyloid in Alzheimer’s disease. In:  Glenner G, ed., Proc. IVIntnatl. Symp. Amyloidosis. New York:  Plenum Press, 1986:709-715.

Selkoe DJ.  Molecular properties of paired helical filaments and senile plaque amyloid fibers in Alzheimer’s disease.  In:  Fisher A, Hanin I, Lachman C, eds., Alzheimer’sandParkinson’sDiseases:  StrategiesforResearchandDevelopment, 30th OHOLO Biological Conference, Eilat, Israel: Israel Institute for Biological Research, 1986.

Selkoe DJ.  Structural proteins in Alzheimer’s disease. In:  Poeck K, Freund HJ and Ganshirt H.  Neurology (Proc. XII World Congress of Neurology).  Berlin:  Springer-Verlag, 1986. 

Kosik KS, Bakalis S, Galibert L, Selkoe DJ, Duffy LK.  Age-related modification of MAP-2.  In: Soifer D.  Dynamic Aspects of Microtubule Biology. AnnNYAcadSci. 1986; 466:420-426.

Selkoe DJ.  Altered structural proteins in plaques and tangles:  What do they tell us about the biology of Alzheimer’s disease?  NeurobiologyofAging 1986; 7:425-432.

Selkoe DJ, Duffy LK, Nukina N, Joachim CL, Podlisny MB, Kosik KS.     Biochemical analysis of amyloid filaments and paired helical filaments and their respective contributions to neuronal degeneration in Alzheimer’s disease.  In:  Davies P, Finch CE, eds.  BanburyReport27:  MolecularNeuropathologyofAging, New York: Cold Spring Harbor Laboratory, 1987:235-252.

Selkoe DJ.  Deciphering Alzheimer’s disease:  the pace quickens.  TrendsinNeuroscience 1987; 10(5):181-184.

Duffy LK, Abraham CR, Berman-Podlisny M, Walsh RL, Selkoe DJ.  HPLC     analysis of proteins from Alzheimer paired helical filaments. AnnNYAcadSci. 1987; 494:369-372.

Selkoe DJ.  Intraneuronal and extracellular filaments in the pathogenesis of Alzheimer’s disease.  In:  Perry G., ed., AdvancesinBehavioralBiology.  Alterations in the Neuronal Cytoskeleton in Alzheimer Disease:  Plenum Press, New York.  1987; 34:97-107.

Selkoe DJ.  Protein chemistry of neurofibrillary tangles and amyloid plaques in Alzheimer disease:  Relation to the cytoskeleton.  In:  Terry R.D., ed., AgingintheBrain:  Raven Press, New York.  1988, pp. 165-181.

Selkoe DJ, Duffy LK, Nukina N, Podlisny MB, Abraham C, Kosik KS.  Molecular pathology of intra- and extraneuronal filaments in brain aging and Alzheimer’s disease.  In:  Miner GD, Richter R, Blass JP, Valentine JL, Winters-Miner LA, eds., FamilialAlzheimer’sDisease:  MolecularGeneticsandClinicalPerspectives.  Marcel Dekker, Inc., New York and Basel, 1989, pp. 137-151.

Selkoe DJ.  Biochemistry of altered brain proteins in Alzheimer’s disease.  In:  Cowan WM, Shooter EM, Stevens CF, Thompson RF (eds)., AnnRevNeurosci. 1989; 12:463-590.

Selkoe DJ.  Aging, amyloid and Alzheimer’s disease.  Editorial.  NewEnglJMed. 1989; 320:1484-1487.

Selkoe DJ.  Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer’s disease.  NeurobiologyofAging 1989; 10:387-395.

Selkoe DJ.  The deposition of amyloid proteins in the aging mammalian brain:  Implications for Alzheimer’s disease.  AnnMed. 1989; 21:73-76.

Kosik KS, Selkoe DJ.  Probes for the molecular components of plaques and tangles point to a broadening view of Alzheimer pathology.  In: Boller F, K atzman R, Rascol A, Signoret JL, Christen Y., eds.,  BiologicalMarkersofAlzheimer’sDisease.  Springer-Verlag, Berlin, Heidelberg, Germany, 1989; pp. 30-38.

Selkoe DJ.  Amyloid ß-protein precursor and the pathogenesis of Alzheimer’s disease.  Cell 1989; 58:611-612.

Joachim CL, Selkoe DJ.  Minireview:  Amyloid protein in AD.  J Gerontol Biol Sci. 1989; 44:77-82.

Selkoe DJ, Podlisny MB, Gronbeck A, Mammen A, Kosik KS.   Molecular relation of amyloid filaments and paired helical filaments in Alzheimer’s disease.  In:  Wurtman RJ, Corkin S, Growdon JH, Ritter-Walker E, eds., AdvancesinNeurology.  Alzheimer’s Disease.  Vol. 51, Raven Press, Ltd., New York, 1990, pp. 171-179.

Selkoe DJ.  Deciphering Alzheimer’s disease:  The amyloid precursor protein yields new clues.  Science 1990; 248:1058-1060.

Selkoe DJ.  Alzheimer’s disease:  New insights into an emerging epidemic.  MedicalUpdate:  BrighamandWomen’sHospital, 1990; Vol. 11, #10.

Selkoe DJ.  The molecular pathology of Alzheimer’s disease.  Neuron 1991; 6:487-498.

Selkoe DJ.  Amyloid protein and Alzheimer’s disease.  ScientificAmerican 1991; 265:68-78.

Joachim CL, Selkoe DJ.  The seminal role of ß-amyloid in the pathogenesis of Alzheimer disease.  In:  AlzheimerDiseaseandAssociatedDisorders, Vol. 6, Raven Press, Ltd., New York, 1992, pp. 7-34.

Selkoe DJ.  Aging brain, aging mind.  ScientificAmerican 1992; 267:135-142.

Selkoe DJ.  Alzheimer’s disease:  New insights into an emerging epidemic.  In:  D. Blau, R.J. Kahana (Eds.), JournalofGeriatricPsychiatry, Vol. XXV, No. 2, International Universities Press, Inc., 1992, pp. 211-227.

Selkoe DJ.  Physiological production of the amyloid ß-protein and the mechanism of Alzheimer’s disease.  TrendsinNeurosciences 1993; 16:403-409.

Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ.  Normal cellular processing of the ß-amyloid precursor protein results in the secretion of the amyloid ß peptide and related molecules.  In:  R.M. Nitsch, J.H. Growdon, S. Corkin, R.J. Wurtman (Eds.), AnnalsoftheNewYorkAcademyofSciences 1993; 695:109-116.

Haass C, Selkoe DJ.  Cellular processing of the ß-amyloid precursor protein and the genesis of Alzheimer’s disease.  Cell 1993; 75:1039-1042.

Selkoe DJ.  Biochemistry of Alzheimer’s disease.  In:  G.J. Siegel et al. (Eds.), BasicNeurochemistry, 5th Edition, Chapter 45, 1994; pp. 919-933.

Selkoe DJ.  Normal and abnormal biology of the ß-amyloid precursor protein.  AnnRevNeurosci. 1994; 17:489-517.

Selkoe DJ.  Alzheimer’s disease:  A central role for amyloid.  JNeuropatholExpNeurol. 1994; 53:438-447.

Selkoe DJ.  Alzheimer’s disease beyond 1994:  The path to therapeutics.  NeurobiologyofAging 1994; 15:S131-S133.

Selkoe DJ.  Cell biology of the amyloid ß-protein precursor and the mechanism of Alzheimer’s disease.  AnnuRevCellBiol. 1994; 10:373-403.

Selkoe DJ.  Amyloid ß-protein precursor:  New clues to the genesis of Alzheimer’s disease.  CurOpinNeurobiol.; 1994; 4:708-716.

Selkoe DJ.  In vitro production of amyloid ß-protein:  A route to the mechanism and treatment of Alzheimer disease.  In:  E. Giacobini, R. Becker (Eds.), AlzheimerDisease:  TherapeuticStrategies, Birkhauser, Boston, 1994, pp. 62-64.

Selkoe DJ, Haass C, Schlossmacher M, Hung A, Citron M, Teplow D.  Normal production of the amyloid ß-protein and the pathogenesis of Alzheimer’s disease.  In:  I. Hanin, A. Fisher, M. Yoshida (Eds.), Alzheimer’sandParkinson’sDiseases:  RecentAdvances 1995; pp. 95-97.

Selkoe DJ.  Deciphering Alzheimer’s Disease:  Molecular genetics and cell biology yield major clues.  JNIHRes. 1995; 7:57-64.

Haass C, Hung AY, Citron M, Teplow DB, Selkoe DJ.    ß-Amyloid protein processing and Alzheimer’s disease.  Arzneim-Forsch/DrugRes. 1995; 45:398-402.

Selkoe DJ.  Alzheimer’s disease.  Missense on the membrane.  News and Views, Nature 1995; 375:734-735.

SelkoeDJ.  Alzheimer’s amyloid of another flavour.   News and Views, NatureMed. 1995;1: 998-999.

Selkoe DJ.  Physiological production and polarized secretion of the amyloid b-peptide in epithelial cells:  A route to the mechanisms of Alzheimer’s disease.  In:  Kosik KS, Christen Y, Selkoe DJ, Alzheimer’s Disease:  Lessons from Cell Biology, Springer Verlag, 1995; pp. 70-77.

Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C.  The roleof APP processing and trafficking pathways in the formation of amyloid ß-protein.  In:  Wurtman RJ, Corkin S, Growdon JH, Nitsch RM. (Eds.), The Neurobiology of Alzheimer’s Disease, AnnNYAcadSci. 1996; 777:57-64.

Selkoe DJ.  Cellular and molecular biology of the ß-amyloid precursor protein and Alzheimer’s disease.  In:  Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL (eds.), TheMolecularandGeneticBasisofNeurologicalDiseases, 1996; Chapter 32: 601-611.

Selkoe DJ.  Alzheimer’s disease:  Abnormal amyloid metabolism and neuronal degeneration. In:  CurrentNeuroscience for the Clinician:  Neuronal Diseases - Molecular Insights and New Therapeutic Strategies.  Continuum 1996; 2: 46-64.

Selkoe DJ.  Amyloid ß-protein and the genetics of Alzheimer’s disease.  JBiolChem. 1996; 271: 18295-18296.

Selkoe DJ.  Cell biology of the ß-amyloid precursor protein and the genetics of Alzheimer’s disease.  In:  Function and Dysfunction in the Nervous System, Cold Spring Harbor Symposia on Quantitative Biology,Vol. 61, Cold Spring Harbor Laboratory Press, 1996, pp. 587-596.

Selkoe DJ.  Alzheimer’s disease:  Genotypes, phenotype and treatments.  Science 1997; 275:630-631.

Selkoe DJ.  Alzheimer’s disease:  From genes to pathogenesis.  In:  Images in Neuroscience, Carol A. Tamminga, M.D., Editor, Am J Psychiatry 1997; 154: 9. 

Selkoe DJ.  Cellular production of amyloid beta-protein:  A direct route to the mechanism and treatment of Alzheimer’s disease.  In:  Folstein M (ed.), Neurobiology of Primary Dementia, ARNMD, 1997; 73: 43-53.

Haass C, Selkoe DJ.  A technical KO of amyloid-ß peptide.  News and Views, Nature 1998; 391: 339-340.

Selkoe DJ.  The cell biology of ß-amyloid precursor protein and presenilin in Alzheimer’s disease.  Trends in Cell Biology, 1998; 8: 447-453.

Selkoe DJ, Xia W, Podlisny M, Hartley D, Walsh D.  Progressive cerebral accumulation of the amyloid ß-protein as the central pathogenetic event in Alzheimer’s disease.  In: Amyloid and Amyloidosis, Proceedings of the VIII International Symposium on Amyloidosis, Rochester, Minnesota, 1998, pp. 448-452.

Selkoe DJ.  Amyloid ß-protein and the cell biology of Alzheimer’s disease.  In:  Wellcome News, Supplement, The Wellcome Trust, 1998.

Selkoe DJ.  Translating cell biology into therapeutic advances in Alzheimer’s disease.  Nature 1999; 399: Supp. A23-A31.

Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ.  Are presenilins intramembrane-cleaving proteases proteases?  Implications for the molecular mechanism of Alzheimer’s disease.   Biochemistry, 1999; 35: 11223-11230.

Selkoe DJ.  Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration.  Curr Opin Neurobiol, 2000; 10: 58-62.

Selkoe DJ,  Wolfe MS.  In search of g-secretase: presenilin at the cutting edge.  Proc Natl Acad Sci USA,  2000, 97: 5690-5692

Selkoe DJ.  Alzheimer’s disease results from the cerebral accumulation and cytotoxicity of amyloid ß-protein.  J. Alz. Dis, 2001; 3: 75-81.

Selkoe DJ.  HYPOTHESIS: Alzheimer’s disease is caused by the cerebral accumulation and cytotoxicity of amyloid ß-protein.  Annals NY Acad Sci, 2000; 924: 17-25.

Selkoe DJ.  Alzheimer’s Disease: Genes, Proteins and Therapy. Physiol Rev, 2001, 81: 741-766.

Selkoe DJ.  Presenilin, ß-amyloid precursor protein and the molecular basis of Alzheimer’s disease.  Clin Neurosci Res 2001; 1: 91-103.

Selkoe DJ.  Presenilin, Notch and the Genesis and Treatment of Alzheimer’s disease.  Proc. Natl Acad Sci USA, 2001; 98: 11039-11041.

Selkoe DJ.  Clearing the brain’s amyloid cobwebs.  Neuron, 2001; 32: 177-180.

Selkoe DJ.  Introducing Transglutaminase into the study of Alzheimer’s disease: A personallook back.  Neurochem Int  2002; 40: 13-16.

Selkoe DJ, Podlisny MB.  Deciphering the Genetic Basis of Alzheimer’s disease.  Ann Rev Genomics and Human Genetics, 2002; 3: 67-99.

Selkoe DJ.  Deciphering the Genesis and Fate of amyloid ß-protein.  J Clin Invest, 2002, 110: 1375-1381.

Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ.  Aß oligomers: Their production, toxicity and therapeutic inhibition.  Biochem Soc Trans, 2002, 30: 552-557.

Hardy J and Selkoe DJ.  The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics.  Science, 2002; 297: 353-356.

Wolfe MS, Selkoe DJ.  Intramembrane Proteases: Mixing oil and water.  Science, 2002, 296: 2156-2157.

Selkoe DJ.  Alzheimer’s disease is a synaptic failure.  Science, 2002, 298: 789-791.

Selkoe DJ, Schenk D.  Alzheimer’s Disease: Molecular Understanding Predicts Amyloid-based Therapeutics.  Annual Review of Pharmacology and Toxicology, 2003, 43: 545-584.

Selkoe DJ, Kopan R.  Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration.  Annual Review  of  Neuroscience, 2003; 26: 569-97. 

Selkoe DJ.  Folding proteins in fatal ways.  Nature, 2003; 426: 900-904.

Selkoe DJ.  Aging, Amyloid and Alzheimer’s disease: A perspective in tribute to Carl Cotman.  Neurochem Res, 2003; 28: 1795-1713.

Selkoe DJ.  Alzheimer’s disease:  Mechanistic Understanding Predicts Novel Therapies.  Ann Int Med, 2004; 140: 627-638.

Walsh DM and Selkoe DJ.   Oligomers on the brain: The emerging role of soluble protein aggregates in neurodegeneration.  Prot Pep Letts, 2004; 11: 213-228.

Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimerís disease. Neuron, 2004; 44: 181-193.

Selkoe DJ.   Cell biology of protein misfolding: The examples of Alzheimer’s and Parkinson’s diseases.  Nat Cell Biol 2004; 6: 1054-1061.

Selkoe  DJ.  Defining molecular targets to prevent Alzheimer’s disease.  Arch. Neurol. 2005; 62: 192-195.

Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ.  The role of cell-derived oligomers of Aß in Alzheimer’s disease and avenues for therapeutic intervention.  Biochem Soc Trans 2005; 33: 1087-1090.

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